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The average length of therapy for the six neonates was 12.

The effect on pain amplification can occur since the glia cell expresses receptors for many neurotransmitters and neuromodulators, synthesizes and releases numerous transmitters, and is capable of producing proinflammatory cytokines, such as IL-1, IL-6 and TNF () all of which can enhance pain transmission and even counter the pain inhibitory effects of morphine.

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If systolic BP is less than 90 mm Hg or pulse is less than 60 bpm, withhold drug.

Opioids, benzodiazepines, and barbiturates are commonly used medications in the treatment of NAS at many pediatric hospitals.

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